Hong Kong is the business hub of Asia, and the Centre is at the business hub of Hong Kong - bustling Wanchai district.

Overlooking famed Victoria Harbour, the Centre is conveniently linked by covered walkways to adjacent luxury hotels, including the Grand Hyatt Hong Kong and the Renaissance Harbour View Hotel. Also close are the MTR -Hong Kong's modern subway system - the airport bus, city buses and ferries, banking, the main post office, and all the shopping and entertainment that Hong Kong is famous for

The Star Ferry, a Hong Kong ferry service, operates 2 routes from the HKCEC across the Victoria Harbour:
HKCEC, Wan Chai - Cultural Centre, Tsim Sha Tsui
HKCEC, Wan Chai - Whampoa Garden, Hung Hom
The fare is HK$2.2 for adults, and HK$1.3 for children.
Currently, the closest MTR metro station serving the HKCEC is Wan Chai Station (exit C) on the Island Line. The proposed North Island Link, an extension of the MTR's Tung Chung Line, will have a station at HKCEC.
In addition, the HKCEC is served by bus routes number 960, 961, 40, and 40M.